Journal of Undergraduate Research


myostatin pathway inhibition, fibroblast activity, novel small molecule


Life Sciences


Exercise Sciences


Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity can become overly abundant and can lead to skeletal muscle fibrosis, decreasing strength and muscle elasticity. This fibrotic condition can lead to muscle wasting disorders, such as muscular dystrophies, that severely decrease the length and quality of life. Previous studies have shown that the TGF-beta signaling family directly increases fibroblast proliferation. It has also been shown that inhibition of myostatin, a member of the TGF-beta family, reduces symptoms of muscular dystrophies and decreases fibrosis. Previous research suggested that a novel small molecule, SGI-1252 (SGI), could serve as a pharmacological inhibitor of myostatin. The purpose of this project was to determine how treatment of fibroblasts with SGI affects proliferation. We hypothesized that SGI would decrease fibroblast proliferation, while myostatin would increase fibroblast proliferation.

Included in

Kinesiology Commons