Journal of Undergraduate Research
Keywords
hyperosmolarity, trophoblast behavior, gestational diabetes, preeclampsia, intrauterine growth restriction
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
Pregnancy necessitates interactions between the mother and the fetus, and the placenta is the medium through which this is accomplished. Many complications during pregnancy, such as intrauterine growth restriction (IUGR) and preeclampsia (PE) arise from abnormalities in trophoblast cells of the human placenta. Trophoblast cells form the connection between the fetus and the uterine wall. We see placental hyperosmolarity in pregnant patients with diabetes, and there are some reports of aberrant trophoblast functioning during IUGR and PE at term, but more needs to be studied regarding the hyperosmolar stress associated with these pathologies and its role in embryo development. Deviation from normal trophoblast function may lead to impaired oxygen and nutrient exchange and may play a significant role in the development of these diseases which include decreased trophoblast invasion and an increased trophoblastic apoptosis. Hyperosmolarity has been seen in placental tissues from patients with gestational diabetes and PE.
Recommended Citation
Mejia, Camilo and Arroyo, Juan
(2015)
"Hyperosmolarity And Trophoblast Behavior In Gestational Diabetes, Preeclampsia, And Intrauterine Growth Restriction,"
Journal of Undergraduate Research: Vol. 2015:
Iss.
1, Article 162.
Available at:
https://scholarsarchive.byu.edu/jur/vol2015/iss1/162