Journal of Undergraduate Research
Keywords
c-Fos, b-cel; mass, diabetes, global health concerns
College
Life Sciences
Department
Nutrition, Dietetics, and Food Science
Abstract
Type 1 and Type 2 diabetes are major global health concerns. Both types of diabetes result in loss of functional β-cell mass, which is defined as the β-cell number multiplied by insulin secretion rate. The number of β-cells is derived from the cellular proliferation and death rates. Increasing functional β-cell mass could cure diabetes through pancreatic islet transplants or by strengthening endogenous cells. Various groups have shown that the β-cells proliferation rate is extremely low after adolescence in the majority of the population. However, β-cell proliferation has been shown to increase during physiological conditions such as pregnancy and obesity (1). This demonstrates that the molecular mechanisms that permit β-cell proliferation can be activated, given the right signals, after adolescence.
Recommended Citation
Ray, Jason and Tessem, Jeffery
(2015)
"c-Fos enhances functional β-cell mass,"
Journal of Undergraduate Research: Vol. 2015:
Iss.
1, Article 150.
Available at:
https://scholarsarchive.byu.edu/jur/vol2015/iss1/150