Genome-Wide Association Study Of Cerebrospinal Fluid Prostatic Acid Phosphatase Levels

Authors

Lyndsay A. Staley, Brigham Young University
John S. K. Kauwe, Brigham Young University

Keywords

genome-wide, association study, cerebrospinal fluid

College

Life Sciences

Department

Biology

Abstract

In genome wide association studies (GWAS), the use of endophenotypes, or intermediate traits, have been found to provide novel insights into understanding the genetics of complex human disease and the pathways and proteins associated with them. Cerebrospinal fluid (CSF) has been shown to contain analytes that may provide promising insight into disease pathways that may not be identified using blood or other biological fluids. The analytes were selected from the Rules Based Medicine, Inc. (RBM) (Austin, TX) Human Discovery Panel 1.0, which includes a range of signaling, structural, and trafficking proteins that have previously shown relationships with human disease pathology. Our research identified a phenotype that is significantly associated with prostate cancer and moderately associated with bone diseases and blood cell diseases. The identification of biomarkers is vital in disease-related genetic understanding as they can provide us with insights into the mechanisms contributing to disease.

Recommended Citation

Staley, Lyndsay A. and Kauwe, John S. K. (2015) "Genome-Wide Association Study Of Cerebrospinal Fluid Prostatic Acid Phosphatase Levels," Journal of Undergraduate Research: Vol. 2015: Iss. 1, Article 126.
Available at: https://scholarsarchive.byu.edu/jur/vol2015/iss1/126