Replication of Gene-Gene Interactions in Large Alzheimer Disease Dataset

Authors

Kevin Boehme, Brigham Young University
Dr. John "Keoni" Kauwe, Brigham Young University

Keywords

gene-gene interactions, Alzheimer disease, neurodegenerative disease

College

Life Sciences

Department

Biology

Abstract

Alzheimer’s disease (AD) is a common and complex neurodegenerative disease. It is the most common cause of dementia and is characterized by the accumulation of amyloid plaques and neurofibrillary tangles. To date, many genetic loci have been found that modify AD risk, but collectively, they explain only a fraction of the heritability of the disease. It is hypothesized that rare variants with large effects as well as epistatic interactions account for much of the unexplained heritability in AD.

Recommended Citation

Boehme, Kevin and Kauwe, Dr. John "Keoni" (2015) "Replication of Gene-Gene Interactions in Large Alzheimer Disease Dataset," Journal of Undergraduate Research: Vol. 2015: Iss. 1, Article 116.
Available at: https://scholarsarchive.byu.edu/jur/vol2015/iss1/116