Journal of Undergraduate Research
Keywords
Alpha 5, nAChR subunits, mouse lung, nicotinic acetylcholine receptor
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
The study of developing tissues is extremely important in the field of biology. Each organ in the body adheres to an extremely complex and organized development process involving specific signaling molecules and pathways. Pulmonary development is no exception. Lung development adheres to intimately orchestrated processes that require precisely regulated reciprocal interactions between developing respiratory epithelium and the surrounding splanchnic mesenchyme. Proper lung development involves both spatial and temporal control of a myriad of factors including transcription factors, growth factors, cell surface receptors, and extracellular matrix constituents. My hypothesis when I began this project was that a5 subunits are expressed in specific lung cell types such as Clara cells in the proximal lung and alveolar type 1 (AT1) cells in the distal lung. I further hypothesized that a5 containing receptors function in signaling during normal development.
Recommended Citation
Porter, Jason and Reynolds, Dr. Paul
(2014)
"The Distribution of the Alpha 5 nAChR Subunits in the Mouse Lung,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 937.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/937