Production of Cytokines Interleukin-6 and Tumor Necrosis Factor Alpha in Human Adrenocortical H295R Cells

Authors

Joseph Johnson, Brigham Young University
Dr. Allan M. Judd, Brigham Young University

Keywords

cytokines, interleukin-6, tumor necrosis factor, TNF, H295R cells

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Difficulties associated with research into the physiology of the human adrenal gland have been alleviated due to the isolation of the human adrenocortical tumor cell-line, NCI-H295R, which retains the ability to produce adrenocortical steroids (e.g. aldosterone, cortisol, DHEA) when grown in culture (1). We investigated whether these cells also produce cytokines, peptides which regulate endocrine and immune function.

Recommended Citation

Johnson, Joseph and Judd, Dr. Allan M. (2014) "Production of Cytokines Interleukin-6 and Tumor Necrosis Factor Alpha in Human Adrenocortical H295R Cells," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 916.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/916