The Specific Binding of Protein’s to the ABC, FG, and DE Enhancer Elements of the Col11a2 Gene

Authors

Kristopher Bennion, Brigham Young University
Dr. Laura Bridgewater, Brigham Young University

Keywords

ABC, FG, DE, Col11a2, enhancer elements, cleft palate, dwarfism, arthritis

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Gene therapy is extensively being studied in many labs for the potential treatment of such disorders as arthritis, cancer, diabetes, and other such disabling diseases. Researchers in Dr. Bridgewater’s lab have been studying the Col11a2 gene in hopes of future treatment of such disorders as cleft palate, dwarfism, and several forms of arthritis. Two years ago we confirmed and established that ABC, DE, and FG were indeed acting as enhancer elements for the Col11a2 gene through various mutations to these specific regions of the gene. These findings have led the lab to do research in the development of a “super enhancer element”, stem cell research, and study into the specific activation of this gene.

Recommended Citation

Bennion, Kristopher and Bridgewater, Dr. Laura (2014) "The Specific Binding of Protein’s to the ABC, FG, and DE Enhancer Elements of the Col11a2 Gene," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 912.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/912