Journal of Undergraduate Research
Keywords
Jak, Stat, adrenal cells, IL-6, dehydroepiandrosterone, DHEA
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
In most mammals, the adrenal cortex produces the hormones cortisol, aldosterone, and dehydroepiandrosterone (DHEA). These hormones have profound effects upon water and salt balance, the inflammatory response, and the metabolism of sugars, fats, and proteins. Because of its importance in maintaining homeostasis, the body highly regulates the adrenal gland. As part of the regulation, the body secretes many different molecules including cytokines. One of the most researched cytokines is interleukin-6, IL-6 (1). Many different cells produce IL-6, including adrenal cortical cells (2). The adrenal cortical cells secrete IL-6 into the extracellular space. IL-6 then binds to its receptor (IL-6 receptor or IL-6R). The specific pathway by which this cytokine activates gene production has been elucidated in other cell types, but the mechanism of IL-6- induced cortisol release is unknown (3).
Recommended Citation
Williams, Brice Jason and Judd, Dr. Allan M.
(2014)
"Jak/Stat Pathway Utilized by Adrenal Cells in Response to IL-6,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 901.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/901