Effects of Prematurity on the Presence of Weibel-palade Bodies in Human Umbilical Vein Endothelial Cells in Situ

Authors

Niloufar Tabatabeai, Brigham Young University
Dr. John S. Gardner, Brigham Young University

Keywords

prematurity, weibelpalade bodies, umbilical vein, endothelial cells, Situ

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Newbom, premature infants have greater susceptibility to infection compared to older newborn infants. Although the reason for greater susceptibility to bacterial infection in premature infants is unknown, there are many reports that focus on neutrophils as the defective cell type in the immature neonatal system. However, it was recently reported by Lorant et al. that in a rat model of inflammation, neutrophils from adult rats failed to migrate efficiently in neonatal rats.’ Furthermore, we found that this defect was associated with decreased expression of Pselectin on the surface of neonatal endothelial cells in situ.

Recommended Citation

Tabatabeai, Niloufar and Gardner, Dr. John S. (2014) "Effects of Prematurity on the Presence of Weibel-palade Bodies in Human Umbilical Vein Endothelial Cells in Situ," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 894.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/894