Journal of Undergraduate Research
Keywords
interleukin-1a, interleukin-6, tumor necrosis factor, TNF-a, human H295r
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
Cytokines are extracellular signaling proteins or peptides that act as local mediators in cell-cell communication. They regulate several endocrine systems and function in the immune process. These agents mediate cellular proliferation within endocrine tissues, regulate hormone secretion, and control aspects of inflammation (1). Interleukin-1a (IL- 1a), IL-6 and tumor necrosis factor-a (TNF-a) are present in normal adrenal glands of rats, bovine and humans. They stimulate and inhibit adrenal hormones. Growth and differentiation of the adrenal gland may also be affected by cytokines. The study of the effects of these cytokines is important because adrenal tumors may cause hypersecretion of the adrenal cortex leading to such disorders as Cushing’s disease (hyperadrenalism).
Recommended Citation
Nelson, Tara Leigh and Judd, Dr. Allan M.
(2014)
"The Effects Of Interleukin-1a, Interleukin-6 And Tumor Necrosis Factor- a On The Growth Of Human H295r Cells,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 889.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/889