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Journal of Undergraduate Research

Keywords

brain aromatase, 5a-reductase, regulatory behaviors, testosterone, rats, phytoestrogen diets

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

In certain brain regions, brain cell differentiation is influenced by hormones present at the time of development. Two hormones, estrogen (estradiol) and testosterone, play significant roles in male and female brain structure differentiation. The major androgen (testosterone) metabolizing enzymes, aromatase cytochrome P450 and 5a-reductase, play critical roles in the conversion of testosterone into estradiol and 5a-dihydrotestosterone, respectively.1

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