Up-regulation of Receptors for Advanced Glycation End-Products (RAGE) in the Lung Results in Significant Tissue Loss and Neonatal Lethality

Authors

Jeff Stogsdill, Brigham Young University
Dr. Paul Reynolds, Brigham Young University

Keywords

up-regulation, RAGE, tissue loss, neonatal lethality, advanced glycation end-products

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The receptor for advanced glycation end-products (RAGE) is becoming an increasingly popular molecule of study after having been initially characterized in relation to a number of diseases such as diabetes, Alzheimer’s and atherosclerosis among others. It has recently been noted that RAGE is found at high quantities in lung diseases such as lung fibrosis, acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD) coupled with emphysema, yet the specific role it plays to date is unknown. In this research, RAGE has been conditionally over-expressed in the mouse lung in order to determine its contribution to pulmonary development and characterize the resulting phenotype.

Recommended Citation

Stogsdill, Jeff and Reynolds, Dr. Paul (2014) "Up-regulation of Receptors for Advanced Glycation End-Products (RAGE) in the Lung Results in Significant Tissue Loss and Neonatal Lethality," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 886.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/886