Journal of Undergraduate Research
Keywords
RAGE, inflammatory lung disease, air pollutants, mouse
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
I was given a research grant of $1,500. My project was centered around discovery of cellsignaling pathways linked to inflammation specific to the lung. We studied a receptor that may be shown to integrally participate in inflammation in such diseases as COPD and Asthma. My studies followed Receptors for advanced glycation end-products (RAGE) which have been implicated in mechanisms of sustained pulmonary inflammation associated with several pathological conditions. This project sought to investigate the direct interaction of particulate matter and RAGE as well as RAGE’s role in perpetuating an inflammatory response in epithelial cells resident to the respiratory tract. This information may prove beneficial in enhancing the diagnosis and treatment of inflammatory pathways that are exacerbated in the lungs of asthmatics when exposed to air pollutants rich in particulate matter.
Recommended Citation
Earley, Tyler and Reynolds, Dr. Paul
(2014)
"RAGE Expression in Inflammatory Lung Diseases Triggered by Air Pollutants,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 881.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/881