Over-expression of AGE Receptors in the Adult Mouse Lung A New Model for the Study of COPD

Authors

Megan Stogsdill, Brigham Young University
Dr. Paul Reynolds, Brigham Young University

Keywords

AGE receptors, mouse lung, COPD, RAGE, chronic obstructive pulmonary disease

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Receptors for advanced glycation end products (RAGE) are receptors that can bind a variety of ligands and are members of the immunoglobin family of cell surface receptors. RAGE is found in many tissue types during inflammatory lesions but is found most abundantly in the lung, where it was subsequently discovered (1). It is known to bind to chemicals found in cigarette smoke (2) and has been implicated as a progression factor in a number of diseases including chronic obstructive pulmonary disease (COPD) (3).

Recommended Citation

Stogsdill, Megan and Reynolds, Dr. Paul (2014) "Over-expression of AGE Receptors in the Adult Mouse Lung A New Model for the Study of COPD," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 876.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/876