Journal of Undergraduate Research
Keywords
selenium, NF-B, prostate cancer cells, cancer, Nuclear-Factor-kappa
College
Life Sciences
Department
Nutrition, Dietetics, and Food Science
Abstract
The American Cancer Society estimates that prostate cancer will account for 30% of new cancers in men, totaling over 189,000 new cases, with 30,200 deaths in 2002 (1). Because of its high prevalence and long latency time prostate cancer is an ideal candidate for chemoprevention (2). Recent research suggests an inverse relationship between high dietary selenium (Se) intake or status and risk for prostate cancer. However, the mechanisms for Se’s protective effects against prostate cancer have not yet been determined. This project focused sharply on a single mechanism by which Se may alter gene expression and affect risk for prostate cancer. Demonstration of this mechanism could suggest other interventions, which may be effective in reducing prostate cancer risk by targeting the same processes.
Recommended Citation
Taylor, Aimee L. and Christensen, Dr. Merrill J.
(2014)
"Selenium Alters NF- B-Regulated Gene Expression in Human Prostate Cancer Cells,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 866.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/866