Selenium Supplementation does not affect the Activity of the Enzyme 8-oxoguanine DNA Glycosylase

Authors

Benjamin J. Wycherly, Brigham Young University
Dr. Merrill Christensen, Brigham Young University

Keywords

selenium supplementation, enzyme, 8-oxoguanine, DNA glycosylase

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Highly reactive oxygen species produce DNA lesions, which are postulated to cause cancer. A particularly common lesion is that of an oxidized guanine residue, 8-hydroxyguanine (8-OHdG). This base is of particular concern because it can mispair with adenine during replication causing a mutation from G:C to A:T. This transversion is found frequently in human cancers.

Recommended Citation

Wycherly, Benjamin J. and Christensen, Dr. Merrill (2014) "Selenium Supplementation does not affect the Activity of the Enzyme 8-oxoguanine DNA Glycosylase," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 863.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/863