The Role of Timing of Dietary Selenium and Isoflavone Supplementation in the Reduction of Prostate Cancer Risk Factors in TRAMP Mice

Authors

Ji Su Park, Brigham Young University
Dr. Merrill Christensen, Brigham Young University

Keywords

dietary selenium, isoflavone supplementation, prostate cancer, TRAMP mice

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer deaths in American men, with a predicted 29,720 deaths in 2013. (1) Previous studies have shown that both selenium (Se) and soy isoflavones reduce risk for prostate cancer when consumed at high levels. (2-3) However, little is known about the effect of Se and isoflavones combined on cancer progression or whether it matters when these supplements are introduced into the diet to decrease cancer progression. In this study, we investigated the individual and combinational effects of Se and soy and the role of timing of supplementation on the progression of prostate cancer in the TRAMP (Transgenic Adenocarcinoma of the Mouse Prostate) mouse model.

Recommended Citation

Park, Ji Su and Christensen, Dr. Merrill (2014) "The Role of Timing of Dietary Selenium and Isoflavone Supplementation in the Reduction of Prostate Cancer Risk Factors in TRAMP Mice," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 851.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/851