Concomitant Treatment of Non-Steroidal Anti-Inflammatory Drugs and Chemotherapeutics on Human Acute T Lymphocytes.

Authors

Janet L. Hart, Brigham Young University
Dr. Kim L. O'Neill, Brigham Young University

Keywords

concomitant treatment, non-steriodal, anti-inflammatory drugs, chemotherapeutics, acute T lymphocytes

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) such as sulindac and acetylsalicylic acid (ASA) are frequently used to relieve pain, clotting, fever and inflammation. Recently, NSAIDs have been shown to decrease the occurrence of colorectal cancer and inhibit mammary cancer in rats. To elucidate this mechanism, further research has been done to show an inhibition of matrix metalloproteinases (MMPs) by NSAIDs in lung and prostate carcinomas. Many current chemotherapeutic agents such as doxorubicin and methotrexate (DOX and MTX respectively) rely on the Fas/FasL (CD95) pathway to induce cell death. Because MMPs are able to cleave membrane-bound Fas, these chemotherapeutics are less-effective.

Recommended Citation

Hart, Janet L. and O'Neill, Dr. Kim L. (2014) "Concomitant Treatment of Non-Steroidal Anti-Inflammatory Drugs and Chemotherapeutics on Human Acute T Lymphocytes.," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 838.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/838