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Journal of Undergraduate Research

Keywords

immune response genes, Murine Experimental Orchitis, mice

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

The research project I proposed entailed mapping the gene or genes that control susceptibility to Murine Experimental Orchitis by using a large backcross population of 110 animals. These animals have been generated by obtaining an Fl population from the susceptible SJL mice and resistant B lO.S mice and crossing the susceptible Fl population with disease resistant BlO.S mice. Through the use of a histological report of the susceptibility of the large backcross population to Experimental Allergic Orchitis, and the use of microsatellite and RAPD markers to identify distinguishing polymorphisms, the gene may be linked to a specific chromosome of the mouse genome and an estimate to the precise location on the chromosome may be given.

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Microbiology Commons

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