Effects of Reverse Transcriptase and Protease Inhibitors on Lymphoid Tissue Viral Load in Murine Retrovirus Infection

Authors

Eric R. Griffiths, Brigham Young University
Dr. Greg Burton, Brigham Young University

Keywords

reverse transcriptase, protease inhibitors, lymphoid tissue, murine retrovirus infection

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

During HIV infection, blocking viral replication has drastic effects on HIV immune complexes maintained on follicular dendritic cells (FDCs): HIV immune complexes quickly drop off FDCs to undetectable levels (1). This was a remarkable and unexpected finding since FDCs typically preserve trapped antigen for months to years. Furthermore, mice have been shown to carry infectious viral immune complexes on FDCs for periods of over nine months in the total absence of viral replication (2).

Recommended Citation

Griffiths, Eric R. and Burton, Dr. Greg (2014) "Effects of Reverse Transcriptase and Protease Inhibitors on Lymphoid Tissue Viral Load in Murine Retrovirus Infection," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 804.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/804