The Effects of DNA Methylation on Nucleosome Positioning

Authors

Marcus Vranes, Brigham Young University
Dr. Steven Johnson, Brigham Young University

Keywords

DNA, methylation, nucleosome positioning, gene expression

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Recent studies have attempted to discover the correlation that exists between DNA methylation and nucleosome positioning, but none have explored the direct effect of DNA methylation on nucleosome formation and positioning. This research is directly testing the effects of DNA methylation on nucleosome positioning, and whether the histone octamer has preferred sequences to which it binds, which will add to our understanding of gene expression and regulation. A better understanding of these concepts will help to aid efforts in gene therapy to improve the quality of life for many people who suffer from various genetic conditions.

Recommended Citation

Vranes, Marcus and Johnson, Dr. Steven (2014) "The Effects of DNA Methylation on Nucleosome Positioning," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 770.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/770