Knockout nBMP2 Mouse Embryonic Fibroblast Cell Line

Authors

Josh Yates, Brigham Young University
Dr. Laura Bridgewater, Brigham Young University

Keywords

nBMP2, bone morphgenic protein, fibroblast cell line, immortalized embryonic fibroblast

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation. They have previously been recognized only as secreted growth factors. Recently, researchers in the Bridgewater lab discovered a nuclear variant of Bone Morphogenic Protein 2 (nBMP2). To better understand the function of nBMP2, our lab generated a mutant mouse line in which nBMP2 is missing from the nucleus. These mice display learning and memory deficits, muscle dysfunction, and abnormal immune responses. In order to validate the mouse model and to study the molecular mechanisms of nBMP2 we have generated immortalized embryonic fibroblast cell line.

Recommended Citation

Yates, Josh and Bridgewater, Dr. Laura (2014) "Knockout nBMP2 Mouse Embryonic Fibroblast Cell Line," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 769.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/769