Proteomics Approach to Solving Alzheimer’s Disease

Authors

Ryan Egbert, Brigham Young University
Dr. John Kauwe, Brigham Young University

Keywords

Alzheimer's disease, AD, serum proteomics profiles

College

Life Sciences

Department

Biology

Abstract

Our project has gone according to plan, with a few small modifications along the way. Initially, we had proposed to incorporate gender profiling in attempt to understand the differences in serum proteomics profiles in men and women. Due to the difficulties in carrying out this aspect of the project, we simplified our project to analyze serum differences between Alzheimer’s and non-Alzheimer’s individuals only. Utilizing the novel capillary liquid chromatography method outlined in my proposal we were able to analyze our serum samples. By comparing the resulting mass spectra using specialized statistical methods we have been able to identify several biomarkers. The information we have found will provide us with important information about the presence of proteomics profiles. We think the results are turning up the information that we’d hoped and hypothesized we’d find.

Recommended Citation

Egbert, Ryan and Kauwe, Dr. John (2014) "Proteomics Approach to Solving Alzheimer’s Disease," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 736.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/736