Assessment of Cingulate Gyrus Integrity in Patients with Alzheimer’s Disease

Authors

Michael J. Larson, Brigham Young University
Dr. Ramona O. Hopkins, Brigham Young University

Keywords

cingulate gyrus integrity, Alzheimer's disease, AD, neurogenerative disease

College

Family, Home, and Social Sciences

Department

Psychology

Abstract

Alzheimer’s disease (AD) is a neurogenerative disease that is characterized by memory loss, language impairments, impaired visuospatial skills, poor judgment, and mood changes. The pathophysiology of AD is typified by a loss of cholinergic cells in the basal forebrain, development of neuritic plaques in the cerebral cortex, neurofibrillary tangles that start in the temporal lobe and progress to other cortical regions, and generalized cerebral atrophy (Kolb & Whishaw, 2001). Increased atrophy is associated with increased severity of dementia (Fox, Scahill, Crum, & Rossor, 1999; O’Brien et al., 2001). The neuropathology and associated atrophy in AD progresses systematically, starting in the limbic system and progressing through the entorhinal cortex and medial temporal lobe (including the cingulate gyrus). Little is known about the effects of AD on the cingulate gyrus.

Recommended Citation

Larson, Michael J. and Hopkins, Dr. Ramona O. (2014) "Assessment of Cingulate Gyrus Integrity in Patients with Alzheimer’s Disease," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 351.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/351