Journal of Undergraduate Research
Keywords
regio, stereoselective photochemical cycloaddition, 4-hydroxycoumarin, alkenes
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
Recent photochemical research has proven helpful in understanding the regio- and stereoselective mechanism of four-member ring formation. When compounds cycloadd— combine either inter- or intramolecularly to form rings—a broad assortment of isomers are generally formed. However, the regio- and stereoselectivity of the cycloaddition process—the tendency of the compounds to combine in specific ways, i.e. the preference for one product over another—can be greatly enhanced through the utilization of a tether group. This tether group can be anything used to control the reacting molecular components involved in a cycloaddition towards combination in a specific orientation. The regio- and stereoselectivity of the reaction, simply termed “selectivity” in general, is of particular interest in natural product synthesis to develop novel, efficient means of producing natural compounds or biologically active agents such as pharmaceuticals.
Recommended Citation
Henneman, Scott and Fleming, Dr. Steven A.
(2014)
"Regio- and Stereoselective Photochemical [2+2] Cycloaddition between 4-Hydroxycoumarin and Alkenes,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 1168.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/1168