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Journal of Undergraduate Research

Keywords

internal ribosomal entry site, human angiotensin 2, Type 1 receptor

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

The study of human genetics has recently exploded into numerous fields and, as a result, our knowledge of genetics and gene related illnesses is growing exponentially. Human DNA undergoes three main levels of control. The first is replication where the genome is reproduced in an exact copy. The second level is transcription, where an RNA polymerase transcribes DNA into mRNA. Finally translation where mRNA, the code for making a protein is recognized by ribosomes. Ribosomes recognize the 5′ region of the mRNA and scan along until they find the start codon to initiate the translation of the mRNA into a protein. This is called the cap dependant mechanism. My research will focus on the translational control of the human angiotensin II type 1 receptor (hAT1R) and how the mRNA is specifically recognized by ribosomes. The hAT1R receptor mRNA translational regulation has serious implications in the role of hypertension and can also be linked to cell growth and indirectly to tumor neovascularization.

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