Synthesis of Systematically Varied Nucleosides as a Logical Approach Toward Inhibitor Design for Nucleoside Transport Proteins

Authors

Lars P. C. Nielsen, Brigham Young University
Dr. Morris J. Robins, Brigham Young University

Keywords

nucleosides, inhibitor design, nucleoside transport proteins, Glucose Transporter I

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

Glucose transporter proteins constitute one class of transmembrane integral proteins that have received much attention in the current chemical literature. Many prominent groups have set out to explore their mechanisms, kinetics, and active sites. Studies have focussed on one of these in particular, Human Glucose Transporter I, the most common and efficient at mediating cellular glucose concentrations. Studies have also proven that certain nucleoside transporters exist, analogous to the sugar proteins, which regulate nucleoside and nucleotide concentrations in cells.

Recommended Citation

Nielsen, Lars P. C. and Robins, Dr. Morris J. (2014) "Synthesis of Systematically Varied Nucleosides as a Logical Approach Toward Inhibitor Design for Nucleoside Transport Proteins," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 1128.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/1128