Journal of Undergraduate Research
Keywords
asymmetric synthesis, anti-tumor antibiotic geldanamycin, antibiotic
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
Geldanamycin, a member of the benzoquinoid ansamycin family, was discovered in 1970 by workers at UpJohn laboratories.1 Scientists were eager to characterize and assess the biological activity of this natural product, first isolated from the bacteria species Steptomyces hygroscpius.2 It was soon learned that geldanamycin functioned as an antibiotic. More importantly, this antibiotic was also shown to check the proliferation of malignant cancer cells.3 This observation has fueled significant interest in geldanamycin as a potential antitumor drug.
Recommended Citation
Simmons, Bryon and Andrus, Dr. Merritt B.
(2014)
"A Partial Asymmetric Synthesis of the Anti-tumor Antibiotic Geldanamycin,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 1125.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/1125