Journal of Undergraduate Research
Keywords
expression, activity, inhibition, canine cyclooxygenase, COX, NSAIDS
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) exhibit their effect by inhibiting the cyclooxygenase (COX) enzymes. However, inhibition of both COX-1 and COX-2 by the administration of NSAIDs to both humans and animals often leads to negative side effects, most commonly gastric toxicity, including ulcers, which may progress to perforation with risk of sepsis. Functional COX-1 and COX-2 are both necessary to maintain the integrity of the gastrointestinal lining. Fueled by the discovery of COX-2 and the elucidation of its biological properties, new NSAIDs have been produced that selectively inhibit only COX-2. This new class of inhibitors effectively reduces pain and inflammation with decreased side effects. COX-2 selective drugs such as celecoxib and refecoxib are now widely used to treat rheumatoid arthritis and osteoarthritis in humans.
Recommended Citation
Wilson, Joel Ellis and Simmons, Dr. Dan
(2014)
"Expression, Activity and Inhibition of Canine Cyclooxygenase,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 1122.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/1122