Cyclooxygenase 1 and 2: Development of Canine InVitro and Whole Blood Assays for Non-Steroidal Anti-inflammatory Drugs

Authors

Nicole L. Hatch, Brigham Young University
Dr. Daniel L. Simmons, Brigham Young University

Keywords

Cyclooxygenase, COX, canine, non-steroidal anti-inflammatory drugs, NSAIDS

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDS) are the basis for a multi-billion dollar pharmaceutical market. Their target, Cyclooxygenase (COX), might from an economic standpoint be considered the most important enzyme known to man (1). NSAIDS inhibit COX from producing arachdonic acid, a precursor to prostaglandins (2). Prostaglandins have been indicated in platelet aggregation, cancer, the processing of pain information in the spinal cord, septic shock, smooth muscle contraction during ovulation, cell proliferation, rheumatoid arthritis and inflammation.

Recommended Citation

Hatch, Nicole L. and Simmons, Dr. Daniel L. (2014) "Cyclooxygenase 1 and 2: Development of Canine InVitro and Whole Blood Assays for Non-Steroidal Anti-inflammatory Drugs," Journal of Undergraduate Research: Vol. 2014: Iss. 1, Article 1097.
Available at: https://scholarsarchive.byu.edu/jur/vol2014/iss1/1097