Journal of Undergraduate Research
Keywords
synthesis, bioconjugate dimers, P-glycoprotein, Pgp
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
Chemotherapy is one of the primary treatments for cancer today. A patient’s life may depend on its efficacy, so when he or she develops multi-drug resistance (MDR) the results can be devastating. MDR, a clinical condition manifested by the failure of chemotherapy, is primarily due to the expression of P-glycoprotein (Pgp), a membrane-bound small molecule transport protein which is found normally in some cells but is greatly over expressed in drug resistant cancer cells1. It is believed that after chemotherapy drugs diffuse into the cell, Pgp effluxes them out using energy from ATP hydrolysis, thus imparting drug resistance.
Recommended Citation
Parker, Emily and Andrus, Dr. Merritt B.
(2014)
"Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of PGlycoprotein,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 1096.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/1096