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Journal of Undergraduate Research

Keywords

reactivation, latent HIV, CD4+, T cells, FDC costimulation

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

I received an ORCA grant for a project entitled “Reactivation of latent HIV in CD4+ T cells through FDC costimulation.” The original hypothesis of this research was that the factor FDCs (follicular dendritic cells) produce to reactivate latent HIV in T cells is a protein signaling molecule that can be identified through analyzing the proteins FDCs produce. While this project is still proceeding, my resources during the last year since I received an ORCA grant have been dedicated to ironing out a few preliminary wrinkles to this project. Specifically, I have troubleshot and optimized the method our lab group uses to isolate follicular dendritic cells.

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