Journal of Undergraduate Research
Keywords
Englerin A, Phyllantus englari, anti-renal cancer agent, core structure
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
Englerin A, which comes from an East African plant, Phyllantus englari, has been found to be an impressive anti-renal cancer agent. It is even more promising than another leading natural anticancer agent, Taxol.1 Englerin A has a unique, complex structure, and its exact mode of action is currently unknown. The key features of englerin A are the cinnamate ester and glycolate ester with an intervening lipophilic cyclic hydrocarbon core. The englerin structure can be effectively mimicked with a more simplified core structure. For this project, I worked on synthesizing an analog of the anticancer agent (-)-englerin A that contains key groups and stereochemistry of the agent, but has simplified core structures.
Recommended Citation
Thompson, Kayleen and Andrus, Dr. Merritt
(2014)
"Design and Synthesis of (-)- Englerin A Mimics,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 1081.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/1081