Journal of Undergraduate Research
Keywords
acetylation of SOD1, tumor stress response, cancer, cytotoxic chemotherapy
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
In cancer patients, a lack of cell apoptosis (programmed cell death) coupled with increased levels of cell proliferation leads to the formation of a tumor. Among the available treatment options, cytotoxic chemotherapy is the most common. The primary purpose of this treatment is to induce tumor cell apoptosis. In many cases, tumor cells develop chemoresistance, rendering chemotherapy ineffective as a method to activate apoptosis. Understanding the mechanisms that lead to chemoresistance is a critical step toward developing methods to increase the effectiveness of chemotherapy treatments.
Recommended Citation
Whited, Matthew and Andersen, Dr. Joshua L.
(2014)
"Acetylation of SOD1 as a Regulator of the Tumor Stress Response,"
Journal of Undergraduate Research: Vol. 2014:
Iss.
1, Article 1075.
Available at:
https://scholarsarchive.byu.edu/jur/vol2014/iss1/1075