Journal of Undergraduate Research
Keywords
monitor peptide, anorexia, endogenous cholecystokinin, CCK, ingestion
College
Family, Home, and Social Sciences
Department
Psychology
Abstract
Cholecystokinin (CCK) is a gut hormone released following the ingestion of a meal. It was first shown in 1973 by Gibbs et al. that administration of exogenous CCK-8 (CCK-8 is the smallest part of the CCK molecule that possesses its biological activity) before a meal leads to a decrease in food intake and the onset of satiety-like behaviors in rats.1 Extensive evidence now exists demonstrating that exogenous CCK-8 can produce a selective decrease in food intakes in humans, as well. By using CCK receptor antagonists to block endogenous CCK or trypsin inhibitors to elevate released endogenous CCK, some evidence is consistent with the possibility that endogenous CCK induces satiety and reduces food intake both in experimental animals and in humans.2,3
Recommended Citation
Talbot, Cory A. and Ervin, Dr. Gregory N.
(2013)
"DOES MONITOR PEPTIDE PRODUCE ANOREXIA THROUGH THE RELEASE OF ENDOGENOUS CHOLECYSTOKININ?,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 500.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/500