Rational design of the metabolite mimics as Novel Antibiotics targeting SAM-I/II Riboswitches

Authors

Dr. Young Wan Ham, Brigham Young University

Keywords

metabolite mimics, novel antibiotics, SAM-I/II riboswitches

College

Marriott School of Management

Department

Chemistry and Biochemistry

Abstract

In our 2009 MEG application, we have proposed structure-based rational design of metabolite mimics based on S-adenosylmethionine (SAM) as novel antibiotics targeting SAM-I/II riboswitches and subsequent development of fluorescence assay to evaluate binding of the designed mimics to SAM-I/II riboswitches.

Recommended Citation

Ham, Dr. Young Wan (2013) "Rational design of the metabolite mimics as Novel Antibiotics targeting SAM-I/II Riboswitches," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 2846.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/2846