The Role of Inwardly-rectifying Potassium Channels in Drosophila Development

Authors

Brandon Gassaway, Brigham Young University
Dr. Emily Bates, Brigham Young University

Keywords

Anderson-Tawil Syndrome, ATS, potassium channels, drosophila development

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

Anderson-Tawil Syndrome (ATS) is characterized by morphological defects including clinodactyly (abnormal curvature of digits), syndactyly (fused digits), micrognathia (small jaw), cleft palate, and hypertelorism (wide-set eyes) as well as periodic paralysis and heart arrhythmia. Mutations in inwardly rectifying potassium (Irk) channels are found in patients with ATS. Expression of mutant Irk channels causes similar physiological and morphological defects in mice.

Recommended Citation

Gassaway, Brandon and Bates, Dr. Emily (2013) "The Role of Inwardly-rectifying Potassium Channels in Drosophila Development," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 2622.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/2622