Organic Synthesis of Sulfonated Glycosphingolipids to Study Natural Killer T Cell Stimulation

Authors

Dylan Pratt, Brigham Young University
Brian Anderson, Brigham Young University
Dr. Paul B. Savage, Brigham Young University

Keywords

organic synthesis, sulfonated glycosphingolipids, NKT, Natural Killer T cells

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

The body’s innate immune system is continuously checking our body for molecular structures of antigens on potential pathogens. The CD1d antigen-presenting cell presents glycolipid antigens to Natural Killer T (NKT) cells. NKT cells start a signaling pathway that produces an inflammatory response. 3’’-O-sulfo-Beta-galactosylceramide has been shown to produce a stimulatory response with NKT cells [1]. This project involves the organic synthesis of structural variations of 3’’-O-sulfo-Beta-galactosylceramide. All of these molecules will be tested on their ability to stimulate NKT cells.

Recommended Citation

Pratt, Dylan; Anderson, Brian; and Savage, Dr. Paul B. (2013) "Organic Synthesis of Sulfonated Glycosphingolipids to Study Natural Killer T Cell Stimulation," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 2620.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/2620