Journal of Undergraduate Research
Keywords
Fcγ-Receptor, NF-κB, follicular dentritic cells, FDC
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
The purpose of this project was to determine the reason why the transcription factor NF-κB is not activated when immune complexes (especially those containing HIV) bind to its Fcγ-Receptor, but is activated in FDC’s when the same immune complex (IC) binds to its Fcγ-Receptor. We believed that certain molecules in B-cells bind to Fcγ-Receptor that are not present in the FDC to block activation of transcription. Our purpose was to successfully isolate these molecules in B cells, and then use them to perform the same function in CD 4 bearing T cells, HIV’s main target during infection. Our goal was to locate and isolate these molecules and identify them. If the activation of NF-κB can be inhibited by these molecules we can use them to inhibit transcription of HIV in infected individuals, decreasing the spread of the disease.
Recommended Citation
Scoville, Jonathan and Burton, Dr. Gregory F.
(2013)
"The role of Fcγ Receptor in activation of NF-κB in Follicular Dentritic Cells,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 2619.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/2619