Journal of Undergraduate Research
Keywords
novel form, cyclooxygenase, non-steroidal anti-inflammatory drugs, NSAID, COX
College
Physical and Mathematical Sciences
Department
Chemistry and Biochemistry
Abstract
For many years, non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat pain, fever, and inflammation. The analgesic, antipyretic, and anti-inflammatory effects of these drugs have been attributed to the ability of these drugs to inhibit the activity of cyclooxygenase (COX) enzymes1. COX enzymes catalyze the rate-limiting step in the conversion of arachidonic acid (an unsaturated fatty acid) to potent signaling molecules called prostaglandins, which in turn mediate the inflammatory process. However, NSAIDs, such as diclofenac, have been reported to induce COX activity in certain cell lines2. These studies were done to determine whether a similar induction of COX in response to diclofenac could be reproduced in human cells.
Recommended Citation
Evanson, Nathan K. and Simmons, Dr. Daniel L.
(2013)
"Induction of a Novel Form of Cyclooxygenase by Non-Steroidal Anti-inflammatory Drugs,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 2611.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/2611