Synthesizing a Solution Phase Combinatorial Library to Discover Potent MDR Reversal Agents

Authors

John T. Prince, Brigham Young University
Dr. Merritt B. Andrus, Brigham Young University

Keywords

multi-drug resistance, MDR, chemodrugs, solution phase combinatorial library

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

The failure of chemotherapy in treating cancer is largely due to a phenomenon known as Multidrug Resistance (MDR). In MDR, cancer cells that have been exposed to a particular chemotherapeutic drug build up resistance not only to the drug originally administered, but to a host of other chemodrugs that may or may not be structurally related.1 P-glycoprotein (Pgp), a large, membrane bound transporter, is primarily responsible for MDR. Pgp acts as a pump to efflux cytotoxic drugs, keeping internal concentrations at less than cytotoxic levels. Although other factors contribute to MDR, it is generally thought that the most promising approach to MDR reversal at this time is the development of potent Pgp transport inhibitors. 2

Recommended Citation

Prince, John T. and Andrus, Dr. Merritt B. (2013) "Synthesizing a Solution Phase Combinatorial Library to Discover Potent MDR Reversal Agents," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 2605.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/2605