Synthesis of Lipid A Analogues and the Study of Their Interactions with Antibiotics

Authors

Glade E. Roper, Brigham Young University
Dr. Paul B. Savage, Brigham Young University

Keywords

lipid A, LA, antibiotics, lipopolysaccharide, LPS

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

Septic shock is a disease that kills over 100,000 hospitalized patients in the United States every year. The mortality rate for those who fall into septic shock is between fifty and eighty percent, and despite advances in medicine this rate has remained constant over the years.1 Septic shock is caused by an inflammatory response to Gram–negative endotoxin, also known as lipopolysaccharide (LPS).

Recommended Citation

Roper, Glade E. and Savage, Dr. Paul B. (2013) "Synthesis of Lipid A Analogues and the Study of Their Interactions with Antibiotics," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 2603.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/2603