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Journal of Undergraduate Research

Keywords

thin film solutions, widespread hospital infection, ceagenin

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

One current problem in medicine is the accumulation of biofilm on medical devices. Bacterial colonization of endotracheal tubes and urinary catheters is the leading cause of hospital-acquired infections. These infections contribute significantly to patient mortality rates and care costs1. Ceragenin-containing thin films have the potential to prevent these infections. Our lab and collaborators have recently shown that the ceragenin CSA-13 in thin films derived from polyurethane undergo sustained release and prevent bacterial colonization of a coated device2. Optimization of this technology has the potential to yield coatings for a variety of medical devices including endotracheal tubes and urinary catheters.

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