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Journal of Undergraduate Research

Keywords

lipidomic analysis, metastatic kidney cancer, cancer types

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

Cancer not only affects individuals and families but has the greatest economic effect worldwide than any other premature cause of death.1 Diverse aspects of cancer biology are under investigation to better understand the mechanism of action of different cancer types, that biomarkers can be identified for early diagnosis, and, most importantly, that a lasting cure can be discovered.32 In the development of cancer, cells undergo a number of phenotypic changes, known as the hallmarks of cancer.2 The hallmarks of cancer are described as sustained proliferative signaling, evading growth suppressors, activating invasion and metastasis, enabling replicative immortality, inducing angiogenesis, and resisting cell death. Each of these hallmarks are caused by genomic mutations that hijack the normal function of a cell. Although the proteins involved in each of these processes have been established, their action are modulated by a relatively unknown lipidome.

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