DETERMINATION OF ANGIOTENSIN II TYPE 2 RECEPTOR PROTEIN INTERACTIONS USING THE YEAST-TWO HYBRID SYSTEM

Authors

Emily Janeen Westover, Brigham Young University
Dr. Terry S. Elton, Brigham Young University

Keywords

Angiotensin II, Ang II, Angiotensin Type 1 Receptor, AT1R, yeast two-hybrid system

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

The renin-angiotensin system plays a central role in water and salt homeostasis, electrolyte balance, and vascular tone maintenance. 1 Each component of this system is a potential effector in the etiology of hypertension. Angiotensin II (Ang II), a component of the reninangiotensin system, interacts with two distinct receptor types, the Angiotensin Type 1 Receptor (AT1R) and the Angiotensin Type 2 Receptor (AT2R). The receptor types 2 probably mediate opposite intracellular effects.3 However, all currently known effects of Ang II involve the AT1R. Because of its novelty and importance, we are investigating the 4 role of the AT2R by determining proteins that interact with this receptor.

Recommended Citation

Westover, Emily Janeen and Elton, Dr. Terry S. (2013) "DETERMINATION OF ANGIOTENSIN II TYPE 2 RECEPTOR PROTEIN INTERACTIONS USING THE YEAST-TWO HYBRID SYSTEM," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 2564.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/2564