A2E-DNA Interaction: A Possible Mechanism for DNA Damage

Authors

Sierra Evelyn Dabell, Brigham Young University
Dr. Heidi R. Vollmer-Snarr, Brigham Young University

Keywords

A2E-DNA interaction, DNA damage, Age-related Macular Degeneration, AMD

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

Abstract

A2E, a common fluorophore found in the retinal pigment epithelial cells of the eye has been shown to have phototoxic properties. For this reason A2E has been implicated in the progressive etiology of Age-related Macular Degeneration (AMD). If the mechanism of cell death can be understood, a possible intervention can be produced. Moreover, the benefits of researching A2E are two-fold. An understanding of bisoxirane-DNA interactions holds the possibility of revealing information about the pathology of AMD and presents itself as a possible chemotherapy through photo-dynamic therapy.

Recommended Citation

Dabell, Sierra Evelyn and Vollmer-Snarr, Dr. Heidi R. (2013) "A2E-DNA Interaction: A Possible Mechanism for DNA Damage," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 2522.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/2522