The Role of Nuclear Bmp2 (nBmp2) in Skeletal Muscle

Authors

Dr. Laura Bridgewater, Brigham Young University

Keywords

nuclear Bmp2, nBmp2, skeletal muscle

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

The goal of this project was to characterize the molecular pathway by which nBmp2 disrupts Ca2+ handling in skeletal muscle of nBmp2 mutant mice. Previously, we had worked with Dr. Chad Hancock’s lab to measure muscle function in nBmp2 mutant mice, and those results showed a slowing in the rate at which Ca2+ is pumped from the cytoplasm back into the sarcoplamic reticulum at the conclusion of a skeletal muscle contraction. Our rationale for this MEG study was that characterizing the muscle dysfunction phenotype in the nBmp2 mutant mice would ultimately lead to a molecular level understanding of the functions of nBmp2 in the nucleus. The purpose of this project was achieved successfully, as described below.

Recommended Citation

Bridgewater, Dr. Laura (2013) "The Role of Nuclear Bmp2 (nBmp2) in Skeletal Muscle," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1823.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1823