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Journal of Undergraduate Research

Keywords

yeast, PAS kinase, glucose homeostasis

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

PAS kinase is a newly discovered member of the nutrient sensing kinases that regulates glucose homeostasis in mice and yeast. The aim of our 2009 MEG “The Function of Yeast PAS kinase” was to characterize the role of a known PAS kinase substrate, Ugp1, as well as to identify novel PAS kinase substrates. We have made significant progress on each of these aims, which has facilitated the preparation of publications, presentations and abstracts. In addition, the findings described below have opened up further research as evidenced by our 2010 and 2011 MEG proposals as well as a 2009 NIH grant proposal. Thus, our 2009 MEG funding has furthered undergraduate education by training undergraduates in basic scientific theory and practice while allowing them to contribute to medically relevant scientific research within a strong mentoring environment. Six undergraduate and one graduate student were dedicated to this project and presented their results at scientific meetings as well as in research articles that are in preparation.

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