A Novel Nuclear Variant of nBMP-2: Role in Ca2+ Transport

Authors

Dr. Laura Bridgewater, Brigham Young University

Keywords

nuclear variant, nBMP-2, Ca2+ transport

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

The goal of this project was to elucidate the role that nBMP-2 plays in Ca2+ transport. In the previous year, we demonstrated that mice that have no nBMP-2 in the nuclei of their cells exhibit delays in the transport of Ca2+ back into the sarcoplasmic reticulum after each muscle contraction. During the period of this award we have extended our focus on nBMP-2 and Ca2+ transport to its effects on neurological function, since learning and memory are also dependent on intracellular Ca2+ transport. To do so, we collaborated with Dr. Jeff Edwards, a neuroscientist in the Department of Physiology and Developmental Biology. This work has led to some very exciting results, as outlined below.

Recommended Citation

Bridgewater, Dr. Laura (2013) "A Novel Nuclear Variant of nBMP-2: Role in Ca2+ Transport," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1820.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1820